When should an idea that smells like research be a startup?

Being a Grahamian startup then subjects the organization to a whole set of constraints and incentives. (Page 3)

The question is whether, if you care about the ultimate success of the idea, a startup is the structure that gives it the best chance.ęęęę (Page 4)

the question of whether a research idea should be a startup might be very discipline dependent. (Page 4)

Too much reliance on a few investors or grant-givers creates the danger that the output becomes ‘things that make investors or grant-givers happy’ rather than things that maximize the potential of the idea, or even make the most money in the long run. (Page 4)

the more the unpredictability in each of the steps smells like uncertainty instead of risk, the less it’s a good idea for the project to be carried forward by a new for-pročt organization. (Page 4)